Learning Resources

Introductory Materials

A Basic understanding of Pharmacokinetic and Clinical Pharmacology principles may be useful prior to more in depth study of pharmacometrics. The following are some online resources in these two disciplines. 

Pharmacokinetic Courses: A First Course in Pharmacokinetics.

A course by David Bourne from the University of Oklahoma

Clinical Pharmacology Course: Principles of Clinical Pharmacology.

  This is a comprehensive course sponsored by NIH Clinical Center given in 2010. It has videos of lectures and downloadable slides.

Clinical Pharmacology Course: Interactive Clinical Pharmacology

Interactive teaching videos developed by Hitlab NZ and Christchurch Hospital/University of Otago Christchurch New Zealand. 

Pharmacometric Materials

Introduction to Pharmacometrics

 Pharmacometrics is the science of applying quantitative principles to the interpretation of pharmacological observations. Rutherford said "Science is either stamp collecting or physics". Pharmacometrics provides a bridge between the stamp collecting (observations) and the physics (understanding) of medical science. The course is a mix of theory and practice. Students learn the fundamentals of modelling biological phenomena using examples from pharmacokinetics and pharmacodynamics. The methods taught have wide application in all areas of medical and biological science.All course materials are available online. Practical use of the hands-on course materials requires access to the following tools: Excel, Berkeley Madonna, Monolix, Phoenix nlme, NONMEM using Wings for NONMEM.

Educational Tools

DDMore Model Repository

The DDMoRe Foundation (DDMoRe) Repository enables access to curated and shared knowledge for the benefit of model-informed drug discovery, development and usage. The Model Repository is an open, publicly-available, free-to-use platform that is community-driven, indexed, fully searchable and supported by peer-review. Together with DDMoRe's unique interoperability framework, these tools facilitate the collaborative development of computational models.

Users can submit their models in a number of formats, but to benefit from all of the repository's features will need to use the PharmML representation.

Basic Pharmacokinetics and Pharmacodynamics Models For Teaching

Most of the commonly used pharmacokinetics and pharmacodynamic models may be found here and used to visualize drug response. The models were created in Stella® and each can be downloaded from this site: http://forio.com/simulate/sarar/

Excel Worksheet For Simple Non-compartmental Analysis

A Microsoft Excel Worksheet for simple non-compartmental analysis.