Mathematical and Computational Sciences (MCS) Special Interest Group (SIG)

Mission

The MCS SIG is a forum for ISoP members sharing common interests in advancing mathematical and computational techniques in pharmacometrics. Our goals include increasing awareness within the ISoP community of existing or emerging MCS methods, offering training in their use, and providing guidance for rigorous and impactful applications. We also maintain ties with mathematical communities around the world to promote pharmacometrics as a scientific discipline generating a variety of interesting theoretical and applied problems.

Objectives

The activities of the MCS SIG are focused on the following themes:

  1. Networking: increase ties between the broader MCS community and pharmacometrics including other SIGs; provide venues for learning and collaboration.
  2. Learning: act as a resource for the pharmacometrics community, including students, through recommended reading, courses, conference sessions, and online discussions and materials.
  3. Collaboration: help identify and publicize existing MCS methods for pharmacometrics needs; promote opportunities for MCS researchers to develop new theories, methods, and computational tools.

Leadership Team


Wojciech Krzyzanski (Chair)

Dr. Krzyzanski received PhD in applied mathematics and MA in pharmacology from the University at Buffalo. He is currently Associate Professor in the Department of Pharmaceutical Sciences at this university. His research interests include PKPD modeling, systems pharmacology, and pharmacometrics. The modeling areas Dr. Krzyzanski specializes in are indirect response models, target mediated drug disposition, pharmacodynamic systems with delays, and physiologically structured populations. The therapeutic domains his research applies to encompass agents and therapies affecting hematopoiesis and iron homeostasis. Dr. Krzyzanski is a member of the ISoP Standards and Best Practices Committee. He serves on the Editorial Advisory Board of the Journal of Pharmacokinetics and Pharmacodynamics.


Helen Moore (Vice Chair)

Dr. Helen Moore is a mathematician and an Associate Director in Quantitative Clinical Pharmacology at Bristol-Myers Squibb in Princeton, NJ. She received her PhD in mathematics in 1995 from Stony Brook University. Her original work in differential geometry focused on shapes that minimize volume under certain constraints. Over a period of 11 years in academia, she won two teaching awards and received a National Science Foundation grant for her research. While at Stanford University, she began collaborating with faculty in the medical school, and shifted her use of optimization techniques to apply them to therapies for cancer, HIV, and hepatitis C.

Dr. Moore was the Associate Director of the American Institute of Mathematics in Palo Alto, California for four years. Her first industry position was in the Modeling and Simulation group at Genentech. She later worked at Pharsight/Certara in both the consulting group and as a software and nonlinear mixed-effects modeling instructor. She returned to the east coast in 2014 to join Bristol-Myers Squibb. She uses mathematics and statistics to model diseases and drug concentrations to improve drug development and to optimize drug regimens.


Gilbert Koch (Secretary)

Dr. Gilbert Koch is an interdisciplinary scientist with mathematical background. Currently he works as Senior Research Fellow in the Pediatric Pharmacology and Pharmacometrics Group at the University Children’s Hospital in Basel, Switzerland. Additionally, he holds an Adjunct Assistant Professor position at the University of New York at Buffalo, NY, USA.

Dr. Koch's interests are pediatric and rare disease related optimal drug dosing questions, modeling of drug-drug interaction at various levels, advanced mathematical modeling techniques such as delay differential equations, mathematical rigorous optimization approaches to compute optimal dosing regimens, target-mediated drug disposition models with more drugs and more targets, and finally development of decision support tools to assist clinicians in daily practice. His PhD was sponsored by Nycomed (now Takeda) and his PostDoc at the University at Buffalo, NY, was funded by Fonds National de la Recherche Luxembourg, Marie-Curie Action.

Executive Committee Members:

  • Dean Bottino
  • Jeroen Elassaiss-Schaap
  • Frank Gibbons
  • Anna Kondic
  • Carl Panetta
  • Craig Thalhauser
  • Coen van Hasselt
  • Yuan Xiong
  • Cynthia J. Musante, ex officio

Elections

Elections are held once per year. The Vice Chair assumes the role of Chair and the Secretary assumes the role of Vice Chair when those respective positions are vacated.